hHR23b mouse mAb

簡要描述：hHR23b mouse mAb
宿主: Monoclonal, Mouse
反應(yīng)性: Human;Mouse;Rat;Monkey;Hamster
應(yīng)用: WB;ICC;IHC

產(chǎn)品型號： YP-Ab-00098

所屬分類：單克隆抗體

更新時(shí)間：2024-11-01

詳細(xì)說明：

hHR23b mouse mAb

抗體，也叫免疫球蛋白（Ig），是一種能特異性結(jié)合抗原的糖蛋白，而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi)，抗體是由于外源性分子的侵襲而產(chǎn)生的?？贵w以一個(gè)或者多個(gè)Y字形單體存在，每個(gè)Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū)，為抗原結(jié)合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異），每一個(gè)抗體的重鏈則決定了它的類或型。

產(chǎn)品詳情

This antibody detects endogenous levels of hHR23b and does not cross-react with related proteins.

免疫原詳細(xì)信息

Purified recombinant human hHR23b protein fragments expressed in E.coli.

相關(guān)試劑

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

背景

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

天津俊達(dá)生物科技有限公司，是從事實(shí)驗(yàn)室耗材銷售的現(xiàn)代化生物科技企業(yè)，公司本著“誠信為本，互利共贏"的核心價(jià)值觀，秉承“以市場為導(dǎo)向，提供服務(wù)"的宗旨為各大院校、科研單位、第三方實(shí)驗(yàn)室檢測機(jī)構(gòu)等提供的產(chǎn)品和服務(wù)。目前公司主要經(jīng)營分子生物學(xué)、細(xì)胞生物學(xué)、免疫學(xué)等生物學(xué)產(chǎn)品，多種實(shí)驗(yàn)室耗材歡迎垂詢！

備注：圖片僅供參考。僅供科研，不可用于臨床。